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Anti-Aging Doctors Sue Professors

June 21, 2005

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Heard the one about the professor who jokingly gave the two osteopathic physicians a bottle of snake oil? Well, they didn’t think it was funny.

In fact, the co-founders of the Chicago-based American Academy of Anti-Aging Medicine (A4M) decided to sue S. Jay Olshansky, professor of epidemiology at the University of Illinois at Chicago, and Thomas Perls, associate professor of geriatrics at Boston University, for $240 million. According to the defamation complaint filed in an Illinois court, Olshansky and Perls conspired to undermine A4M’s scientific credibility and in turn to harm the business prospects of Ronald Klatz and Robert Goldman, the two founders. The result, according to the complaint, was several professional disappointments, including the loss of a $20 million contract for Medical Development Management, an Illinois corporation in which Klatz and Goldman are the principal shareholders.

It is not the first time Olshansky and Perl have criticized A4M, although they maintain that their criticisms are based in science. In fact, the two guest edited an issue of The Journal of Gerontology: Biological Sciences that was devoted to clearing up the hype about anti-aging remedies. It was at a conference on anti-aging that Olshansky gave a bottle of vegetable oil, labeled “snake oil,” to Klatz and Goldman, who were not there. That honor was added to the "Silver Fleece" award for "the most outrageous or exaggerated claims about slowing or reversing human aging," for which Olshansky and Perls helped select the winner.

Olshansky said he is by no means against searching for ways to slow or stop aging. In fact, he has conducted aging research himself. "I’m a strong supporter of anti-aging research," he said. “But it’s my job to protect public health, and inform the public about the truth of what we know and what we don’t know. Right now, the claim that we can stop or reverse aging isn’t really much of an issue for debate among serious scientists.”

Among A4M’s remedies that worry him is human growth hormone. In one of his books, Klatz called HGH proven for age-reversal. HGH has been shown to temporarily slow some signs of aging, but some research suggests reason to be concerned about possible side effects.

Experts said the case is an uncommon attack on professors speaking about issues within their field of study. Because of the cost of litigation, lawsuits "can have a chilling effect on academic research," said Jonathan Knight, director of the Office of Academic Freedom and Tenure at the American Association of University Professors, who said cases like this are "as rare as hen’s teeth."

Knight said he was surprised that the lawsuit did not name the universities, which “have deeper pockets,” as defendants as well. But other experts thought the whole point might be to scare the professors with the cost of litigation. “Even the cost of the discovery process can be extremely expensive,” said Sandra Baron, executive director of the Media Law Center in New York, who said she is not aware of other cases just like this.

The University of Illinois at Chicago is backing its professor in the case, and footing the legal bill. "The university has become involved because it is an issue of academic freedom,” said Bill Burton, a spokesman. "Professor Olshansky is doing his job … to search for the truth and speak it. That is the purpose of a research university. The university is defending its purpose.”

Klatz and Goldman chose not to comment on the case, but their lawyer disagreed strongly with Burton’s sentiment that Olshansky was doing his job. “This is not a case about an ‘academic’ debate,” said Sigmund S. Wissner-Gross. “The case is about alleged conduct by two individuals far removed from the classroom and not in their professional capacities.”

“That’s funny,” Olshansky said of the claim that he was acting outside his role as a professor and researcher. “This was an international conference on anti-aging in Australia,” he said of the venue for the silver fleece award, “in a session devoted to anti-aging, the hype and the reality. I couldn’t be anymore within what I do.”  

The complaint also mentions Olshansky’s visit to an A4M conference in Las Vegas in 2003. It says that Olshansky met the executive vice president of Market America Inc., and that he denounced several of their products as unproven and useless, threatening to make his statements public, when he found out Klatz and Goldman had helped formulate them. Olshansky said he recalls the meeting. “It was a friendly three-way conversation with me, him, and the [professor from UCLA] who was running the meeting.”

Olshansky said he asked his typical two questions: 1) What does the product do? 2) Where’s the scientific evidence? When the Market America representative told Olshansky there had not been sufficient clinical trials, Olshansky said he told him “maybe it would be a good idea to do that.” Olshansky said the the man then asked if he would do it. “I said that probably wouldn’t be a good idea. It was a friendly inquiry, trying to evaluate the evidence, just as it should be in science. Of course, Klatz and Goldman were not there.” Market America later backed out of its contract with Klatz and Goldman, who claim in court papers that the products were tested.

Klatz and Goldman first sued Olshansky and Perls last fall, but the case was dismissed in the spring, according to Olshansky. The new case is a modified version of the original.

Olshansky said he has received strong personal support from many colleagues, and that he will not stop speaking out.  "We will not be intimidated," he said. "This is the pursuit of a scientific issue by scientists. I am a professor of public health and that’s part of what I do. I will continue to speak freely for the rest of my life."

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Comments on Anti-Aging Doctors Sue Professors

  • You can't stretch concrete...
  • Posted by David L. Kern , The medical mindset as part of the problem on June 21, 2005 at 5:04pm EDT
  • There are several obvious problems inherent to anti-aging medicine. The most glaring of all, however, is the seeming impossibility of clinically controlled studies to test various therapies.

    Scientists at the University of Washington announced just a month ago that they had successfully extended life span in mammals by increasing catalase expression in mitochondria. This study essentially proves that the free radical theory of aging, now nearly 50 years old, is true.

    Let us suppose then that we have a substance proven to increase intracellular catalase expression and activity in animals (we do.) How would we test this in humans?

    How do we design a multigenerational double-blind placebo-controlled trial with a 100 to 140 year duration?

    How many more 100+-year trials would we need to confirm the results? Do we need to wait through 500 years of clinical trials to satisfy the critics of anti-aging medicine?

    I ask these questions to point out that there will NEVER be enough validation to satisfy some. I am not suggesting that there is no "snake oil," or that we blindly believe every claim.

    I am suggesting, however, that take the time to intelligently and carefully review the wealth of data available on certain compounds that show true anti-aging results in animal and cell studies.

    I think it would be wonderful for humans, five or ten generations from now, to use anti-aging methods proven to extend life in those hundred year human trials. I am more interested, I must confess, in utilizing what we can discern and extrapolate from the existing research, and put it to work now- in my lifetime.

    I do not know Professor Olshansky. From his comments, he seems to be a reasonable person. But it's very easy to set up an impossible testing paradigm, and then take potshots at those who cannot meet the criteria.

    The medical mindset is very entrenched and difficult to influence. It tends toward the arrogant and didactic. "We don't know how to do it yet" too often becomes "it can't be done."

    My brother went to a specialist this year in search of relief from an irritated colon. The doctor told him that diet had nothing to do with his problem.

    Correct me if I'm wrong, but I believe the colon is still part of the alimentary canal, the purpose of which is to digest and eliminate food. The statement that diet is unrelated simply defies common sense.

    Perhaps Drs. Klatz and Goldman are sincere in their efforts; perhaps not. But I believe they and physicians like them should be credited for at least stretching the concrete boundaries of the conventional medical mindset.

    I hope Professor Olshansky is aware of the accelerated research into anti-aging, and the thousands of serious doctors and scientists who are working in this exciting field. There is much to be learned from the cutting edge.

    Until the consecutive multigenerational human trials are complete, I have no choice except to depend on the advances in cell and animal research.

    Careful and intelligent study of the research has led me to the personal conclusion that I can, unquestionably, intervene in the process of aging with substances which increase catalytic antioxidant expression and activity.

    If I'm wrong, no real harm done.

    If I'm right?

    See you in a few hundred years...

    David L. Kern
    New Health & Longevity

  • ANTI-AGING
  • Posted by STEPHANIE LEDERMAN , EXECUTIVE DIRECTOR at AMERICAN FEDERATION FOR AGING RESEARCH on June 22, 2005 at 10:47am EDT
  • I AM QUITE SURPRISED BY THE COMMENTS OF THE EDITOR WHO QUITE FRANKLY HAS NOT DONE HIS HOMEWORK. DR. OLSHANSKY IS A RESPECTED RESEARCHER AND IS SPEAKING FOR THE LEGITIMATE SCIENTISTS. WE AT THE AMERICAN FEDERATION FOR AGING RESEARCH FUND SCIENTISTS WHO ARE SEARCHING FOR CLUES INTO THE AGING PROCESS. WE HAVE GIVEN OUT MORE THAN FIFTY MILLION DOLLARS OVER THE PAST 24 YEARS. WE ARE CONCERNED BY THOSE WHO BOAST CURES AND PROMISES OF LONGEVITY WITHOUT SCIENTIFIC MERIT THAT ULTIMATLEY CONFUSE THE PUBLIC. YES, LET SCIENCE CONTINUE ITS WORK BY ADVOCATING FOR MORE FUNDING, NOT QUACKERY!

    STEPHANIE LEDERMAN
    EXECUTIVE DIRECTOR
    AMERICAN FEDERATION FOR AGING RESEARCH

  • To Stop Aging, First Stop Fighting
  • Posted by Leonid Gavrilov , Ph.D. at Center on Aging, University of Chicago on June 22, 2005 at 4:53pm EDT
  • I have posted my comments "To Stop Aging, First Stop Fighting" at:

    http://longevity.scienceboard.net/index.php?m=20050621

  • professors sued
  • Posted by Michael Boxenbaum , CEO at Anti-Aging & Vitality Centers on July 19, 2005 at 4:55am EDT
  • Open and serious discussion in any area of medicine should always be welcomed and engaged. I do not fault the professors for their right to their views, it is their insulting manner which I believe raised eyebrows and ire.

    There is so very much in the field of anti-aging that is on the correct path to improving and valuing human life. I trust and hope that the professors are not insinuating that entire A4M is tainted in any way.

    It would be nice to have completed, prospective, randomized, trials of all that is presented, but, realty is that this is not always practical. HBOT for example has proved, anecdotally, for years to have merit in various treatments. Various surgical procedures have been treated in this manner. As is the case with various forms of alternative therapies. Strive for science and results. But, do not always discount or diminish the anecdotal that consistently yields positive outcomes.

    Michael Boxenbaum

  • Research is hard to do.
  • Posted by M. King on November 7, 2005 at 7:00pm EST
  • To paraphrase a famous pundit:

    "Anecdotal medicine is the last refuge of the scoundrel."

    Was it Mark Twain or Thomas Paine?