The National Institutes of Health on Friday said it was considering issuing new regulations to govern financial and other conflicts of interest in biomedical research and invited interested parties to weigh in on a set of possible changes. In an advance notice of proposed rule making published in Friday's Federal Register, the NIH and its parent agencies, the Public Health Service and the Department of Health and Human Services, posed a set of questions that have emerged in recent years as biomedical researchers' ties to industry have come under increasing scrutiny. Should researchers have to report more information about their sources of income to the institutions, even if they do not believe it is germane to their work? Should the minimum threshold of payment that is perceived to be a financial conflict of interest be raised? Should research institutions be required to establish committees to review their employees' financial disclosures?