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Sen. Arlen Specter's defeat in Tuesday's Democratic primary in Pennsylvania will end a political career in which the senator was frequently a key ally of advocates for biomedical research and education. Specter, a Republican until last year, was for many years the ranking Republican on the Senate appropriations subcommittee with jurisdiction over spending on education programs and the National Institutes of Health -- and he backed spending increases in both areas, in particular for the NIH. Joe Sestak, who defeated Specter, doesn't differ from him significantly in views on those issues.