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City University of Seattle, a 40-year-old nonprofit institution that serves mostly adults, will become part of the National University System, under an arrangement announced by National officials Wednesday. City University operates significant teacher education and business programs, and provides a significant amount of its instruction online. Under the new arrangement, which has already won approval of the Northwest Commission on Colleges and Universities, it will remain an independent institution but be part of National's growing system of nonprofit institutions, which also includes John F. Kennedy University (as of 2008), WestMed College, and National University itself, which is headquartered in San Diego but has campuses throughout California and surrounding states.

National is one of a small number of growing systems of nonprofit institutions that have been adding colleges with related missions and that are seeking additional resources to either survive or thrive. The TCS Education System, for instance, took over Pacific Oaks College in 2010.