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Flipping the classroom is particularly beneficial for women and students with low grades, according to a new study by researchers at Yale University and the University of Massachusetts at Amherst. The findings emerge from five years' worth of data gathered from an upper-level biochemistry course first taught in a traditional setting, then flipped. Students in the flipped sections of the course scored 12 percent higher on exams than students in sections that used lectures, and the flipped sections also showed less of a gap between the exam scores earned by male and female students. Students with the lowest overall grade point averages appeared to benefit the most from flipping the classroom. The study appears in the December issue of CBE -- Life Sciences Education, a journal of the American Society for Cell Biology.